- Citicoline 250mg - Authentic CDP-Choline | 21% choline base content.
- The form of choline most used by students and individuals with high cognitive demands.
- Raw material: Cognizin® - Developed by the prestigious company Kyowa Hakko.
- Cognizin® is a citicoline patent supported by scientific studies.
- Ultra-pure | Allergen-free | High stability | High concentration dosage.
- Suitable for vegan diets - Capsules made with vegetable coating.
Cognizin® Citicoline - The most prestigious raw material
Citicoline (CDP-Choline) (Cognizin®) 250mg from Essentialseries is a dietary supplement developed in single-ingredient presentation and vegetable capsule format, based on the compound citicoline, also known as CDP-choline, with Cognizin® as the raw material, a renowned patented ingredient from the Japanese company Kyowa Hakko.
Kyowa has made great efforts in the development and optimization of both the approach to Citicoline and its production, achieving its maximum performance at the end of 2023 with the opening of facilities entirely dedicated to this specific patent, located in the city of Hofu, Yamaguchi Prefecture, Japan. Cognizin® is positioned in the current market as the international reference patent for the compound citicoline.
HSN's Citicoline (Cognizin®) is a high-concentration product (250mg/capsule), suitable for vegans, thanks to its development with vegetable capsules made from a derivative of vegetable cellulose.
Discover Cognizin® and all the properties that citicoline offers you
Citicoline vs Choline - Understand the differences
CDP-choline is a member of the phosphocholine class. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. Choline is the original compound of the choline class, consisting of ethanolamine with three methyl substituents attached to the amino function; it is a basic component of lecithin found in many plants and animal organs and is important as a precursor to acetylcholine.
Citicoline is a presentation derived from choline, as its full name is citidine-5-diphosphocholine: The union of a citidine molecule, another of choline, and a bond of two phosphate groups at carbon 5.
What does this mean? It means that citicoline is a form of choline, which contains choline itself, in a base concentration that is around 21% of its composition; you can find this information in the nutritional table of our product: Each 500mg of Cognizin® provides 106.5mg of Choline base.
The chemical properties of citicoline that differ from elemental choline or other forms of choline such as bitartrate have led to both scientists and users focusing on its application and use in the fields of study and concentration with this form of the compound, so if your interest lies in these fields of application, citicoline is ideal for you.
Citicoline Dosage - Range and Effectiveness
Citicoline has a clearly established range of effective use, which varies between 250 and 500mg per day.
We have developed our Citicoline product based on these criteria to offer you all the dosage possibilities so that you can enjoy the compound in a complete, comfortable, and simple way.
Each of our capsules provides 250mg of citicoline, which is the minimum daily content of this compound recommended for benefiting from its properties; however, after reviewing the published scientific literature, our recommendation is to use 2 capsules per day, to fully enjoy the properties of CDP-Choline in its higher rangeof effective dosage: 500mg.
At HSN, we develop our formulas after an important project of exhaustive review of each ingredient to find the most significant scientific evidence; and we design our products to combine guaranteed safety + total effectiveness + practicality in their use.
Cognizin® - A Patent with Scientific Backing
Cognizin® is citicoline, just as you can find it in our product where we do not use a trademarked raw material: Citicoline (CDP-Choline) 250mg.
Regarding the question of what makes citicoline special, the answer lies in Kyowa's production process and its extensive experience in the field of production of biocompounds, including choline derivatives; but regarding the compound content per capsule, purity, or properties, Cognizin® citicoline does not differ from other citicoline presentations as long as they are of high quality, such as HSN products.
In addition, Cognizin® is renowned for its extensive scientific research, as with the reputation that precedes its manufacturer, which is positioned as one of the leading and reference companies in R&D in dietary supplements, especially amino acids; many researchers have chosen this specific raw material for their scientific studies as a sign of their confidence in the quality and purity of citicoline.
Many of the positive effects that we know today and associate with citicoline have been discovered thanks to the use of Cognizin® as the raw material for the study, hence Cognizin® is considered as a reference raw material internationally, with a large volume of scientific trials published in prestigious journals, using this specific raw material:
- Nakazaki, E., Mah, E., Sanoshy, K., Citrolo, D., & Watanabe, F. (2021). Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Nutrition, 151(8), 2153–2160.
- Silveri, M. M., Dikan, J., Ross, A. J., Jensen, J. E., Kamiya, T., Kawada, Y., … Yurgelun-Todd, D. A. (2008). Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine, 21(10), 1066–1075.
- McGlade, E., Agoston, A. M., DiMuzio, J., Kizaki, M., Nakazaki, E., Kamiya, T., & Yurgelun-Todd, D. (2019). The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. Journal of Attention Disorders, 23(2), 121–134.
- McGlade, E., Locatelli, A., Hardy, J., Kamiya, T., Morita, M., Morishita, K., … Yurgelun-Todd, D. (2012). Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food and Nutrition Sciences, 03(06), 769–773.
Why Kyowa Hakko as a raw material producer?
Kyowa Hakko Bio succeeded Kyowa Hakko Kogyo in its biochemical business and was established in 2008.
In the words of its director:
'Leveraging our state-of-the-art fermentation technologies, Kyowa Hakko has made substantial contributions to the health and well-being of people worldwide by commercializing a variety of useful chemicals, including various amino acids, nucleic acid-related substances, vitamins, bioactive substances, pharmaceuticals, as well as oligosaccharides and dipeptides.'
Cognizin® is not the first Kyowa patent we work with at HSN, as we have previously incorporated the raw material of Kyowa Quality® Glutamine, a reference in sports nutrition and healthy eating.
With the pillars of: Passion, Integrity, and Diversity, Kyowa shares a good part of HSN's vision regarding quality and effectiveness in the development of its ingredients, and what better than combining Kyowa's internationally renowned patents with the manufacturing of products with quality and IFS Foods certification by HSN, to provide users with the best purchasing options on the market.
With all the guarantees of HSN manufacturing - Effectiveness + Safety
At HSN, we work with a closed end-to-end system that allows us to have control over the entire custody process of the ingredients we work with, certifying important aspects such as:
- That our developments are 100% ours, without limitations imposed by third-party manufacturing.
- That the ingredients received are analyzed and meet all established quality and safety conditions.
- That allergen exposure is limited, in storage and throughout the manufacturing process, guaranteed thanks to our clean rooms.
This whole system is optimal, as it allows us as manufacturers to guarantee the total effectiveness, safety, and integrity of each and every product you receive at your home, as they have been conceived and developed by our specialists in dietary supplements research and manufactured by our specialized factory technical operators.
Furthermore, despite the total control of the process, the procedure is not opaque, as we not only share a lot of information in our communication channels about projects, procedures, and other aspects of our manufacturing, but the entire process is audited by specialized companies in manufacturing quality certification, thus, HSN is certified with GMP, HACCP, ISO, IFS FOOD, among others, ensuring that not only do we follow controlled procedures to avoid any inconvenience, but also that the information on our labeling is completely truthful, and that the quality of the processes we maintain complies with the highest standards of the food industry (being the first company in Spain to manufacture different types of dietary supplements, in the same factory, to obtain IFS Food certification).
Who benefits most from using Citicoline?
Citicoline is usable by all kinds of people, being especially interesting for those seeking to benefit from the properties of choline as a basis: Liver function, homocysteine and lipid metabolism *.
The specific form of CDP-Choline is especially appreciated among students and workers, athletes, or other profiles with high cognitive and attentional demands.
Where can I find citicoline in HSN?
You can find citicoline in our own formulas such as our Neurostimulant: Evobrain, which contributes to normal intellectual performance thanks to its content of vitamin B5. Ideal for students
And in our Brain Care, a formula aimed at caring for neurological health and the brain, thanks to the action of Ginkgo biloba which contributes to mental and cognitive activities and Huperzia serrata which improves overall mental functioning. Ideal for older people and as a break between periods of use of Nootropics with stimulants, like Evootropic.
Ideal combinations with Citicoline
Citicoline can be used in combination with many compounds, but the most frequent uses are:
As a well-known and appreciated combo among students and people with high cognitive demands, such as chess players, poker players, or professionals in accounting, banking, and related sectors.
And if you want to add a 'plus' to this combination, you can add Extended Release Caffeine, or Evocaffeine, if you are looking for different release speeds, with an initially noticeable stimulation but a prolonged duration of effectiveness, ideal for long-duration activities.
Bibliographical references
- Secades, J. J., & Gareri, P. (2022). Citicoline: pharmacological and clinical review, 2022 update. Revista de Neurología, 75(S05), S1–S89.
- Świątkiewicz, M., & Grieb, P. (2022). Citicoline for Supporting Memory in Aging Humans. Aging and Disease, 14(4), 0.
- Jasielski, P., Piędel, F., Piwek, M., Rocka, A., Petit, V., & Rejdak, K. (2020). Application of citicoline in neurological disorders: A systematic review. Nutrients, 12(10), 1–20.
- Al-Kuraishy, H. M., & Al-Gareeb, A. I. (2020). Research paper: Citicoline improves human vigilance and visual working memory: The role of neuronal activation and oxidative stress. Basic and Clinical Neuroscience, 11(4), 423–432.
- Grieb, P. (2014). Neuroprotective properties of citicoline: Facts, doubts and unresolved issues. CNS Drugs, 28(3), 185–193.
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